Lovastatinum [Latin]

Lovastatinum [Latin] Brand names, Lovastatinum [Latin] Analogs

Lovastatinum [Latin] Brand Names Mixture

No information avaliable

Lovastatinum [Latin] Chemical_Formula

C₂₄H₃₆O₅

Lovastatinum [Latin] RX_link

http://www.rxlist.com/cgi/generic3/altocor.htm

Lovastatinum [Latin] fda sheet

Lovastatinum_[Latin] FDA

Lovastatinum [Latin] msds (material safety sheet)

Lovastatinum [Latin] Synthesis Reference

R. L. Monaghan et al., U.S. Pat. 4,231,938 (1980)

Lovastatinum [Latin] Molecular Weight

404.54 g/mol

Lovastatinum [Latin] Melting Point

174.5 ^oC

Lovastatinum [Latin] H₂O Solubility

0.0004 mg/mL

Lovastatinum [Latin] State

Solid

Lovastatinum [Latin] LogP

Lovastatinum [Latin] Dosage Forms

Tablet

Lovastatinum [Latin] Indication

For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia; For primary prevention of coronary heart disease

Lovastatinum [Latin] Pharmacology

Lovastatin, an antilipemic agent produced by fermentation of Aspergillus terreus, is the first of a class of lipid-lowering agents known as the HMG-CoA reductase inhibitors. Lovastatin is used to treat hypercholesterolemia, to slow coronary atherosclerosis, and to prevent myocardial infarction and stroke. Lovastatin, like simvastin and unlike pravastatin, is a prodrug, concentrating active drug in the liver during first-pass circulation.

Lovastatinum [Latin] Absorption

30%

Lovastatinum [Latin] side effects and Toxicity

LD₅₀>1000 mg/kg (orally in mice)

Lovastatinum [Latin] Patient Information

PATIENT INFORMATION

Lovastatin is used to lower high cholesterol levels. This medication should
not be taken if you are pregnant, nursing, or have liver disease. Lovastatin
should be taken with the evening meal. This medication may cause increased
sensitivity to sunlight. Use sunscreens and wear protective clothing until
degree of sensitivity is determined. Notify your physician if you develop
blurred vision; skin rash; muscle pain, weakness, or cramps; unexplained fever,
or yellowing of the skin or eyes.

Patients should be advised about substances they should not take concomitantly
with lovastatin and be advised to report promptly unexplained muscle pain,
tenderness, or weakness (see list below and WARNINGS, Myopathy/Rhabdomyolysis ).
Patients should also be advised to inform other physicians prescribing a new
medication that they are taking MEVACOR .

Lovastatinum [Latin] Organisms Affected

Humans and other mammals